Colby 正在被一个名叫 Kirkland的间谍审问，这个间谍给了一个手铐钥匙，并且告诉他怎么逃生，Don和他的团队要从Colby身上得到一些信息，而且必须断定如果这些信息可靠的话，那就意味着对于Colby作为一个双重间谍的一切事情未必是他所表现的那样。 当一个年轻人驾驶着一辆专为公路...赛车而设计的爱车时，他撞死了一个人并且致其他一些无辜的人受伤。Don 断定出这辆车是由从全国各地偷来的零配件拼凑出来的。他说服Charlie 帮他断定出为什么会出这件车祸。而此时驾驶员仍在医院处于昏迷当中。医生告诉他们他有多重部位受伤。包括他头部左侧的猛烈撞击。一个鞋印表明有人在事故现场踢了他的头部。Colby与他的队员返回。 当一个业余爱好者在总部展示了一盒视频录象带，这个录象带显示的是一名女孩死在浴缸中。这直接导致联邦调查局到一个男演员的家中和一个女士用来"约会服务“的家里搜查。在那里他们发现了非法销售的DVD，勒索案和过去的一棕谋杀案。 Rob Morrow扮演的FBI探员和他那具备超乎常人数学天才的弟弟Charlie一起侦破了在L.A发生的大范围严重罪案。Charlie对案件独特的思考方式让Don的同僚Terry Lake 和David Sinclair 都感到十分惊讶。与此同时Don和Charlie的父亲对于两个儿子专注执着的个性会否使彼此在工作中产生摩擦感到担心。Larry Fleinhardt 是Charlie的学院导师，他希望Charlie专注于学术研究而不是浪费无谓的精力帮助警方破案。 NUMB3RS将会通过真实的事例，反映数学理论是如何被应用到警方的调查之中，从而破解一件件匪夷所思的罪案。
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