由派琵•蒙格玛丽（Poppy Montgomery）饰演的卡丽•威尔斯（Carrie Wells）曾经是一位高深莫测的警探——她拥有超群的记忆力。到过的所有地方、所有谈话、所有喜怒哀乐，卡丽都能准确无误地记录在脑子里。她不由自主地牢记着她所经历的一切，却唯独想不起一件事情：多年前她妹妹被谋杀时的细节。 卡丽努力地想要摆脱过去，但在为一桩杀人案接受问讯时，她却意外邂逅了她的老同事兼前男友——纽约警察局的艾尔•伯恩斯探员（Al Burns，迪伦•沃尔什Dylan Walsh饰）。 艾尔•伯恩斯的小团队有如下成员： 探员麦克•科斯特洛（Mike Costello，迈克尔•加斯顿Michael Gaston饰），艾尔的左膀右臂； 探员罗•桑德斯（Roe Saunders ，凯文•兰金Kevin Rankin饰），队伍里的小菜鸟； 探员妮娜•英娜拉（Nina Inara ，戴雅•维迪雅Daya Vaidya饰），熟知市井民情的火辣女警。 休整之后回归工作的卡丽感觉很不错。尽管艾尔偶尔让她不自在，卡丽还是决定加入他的团队，共同侦破各种谋杀——当然，包括那桩她妹妹被杀的悬案。卡丽的职责就是：记住所有的东西。
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