A chronicled look at the criminal exploits of Colombian drug lord Pablo Escobar.
故事聚焦于哥伦比亚毒枭Pablo Escoba，该角色由Wagner Moura出演。
在《权力的游戏》 中 饰演“红毒蛇”奥柏伦马泰尔的Pedro Pascal将出演一位墨西哥禁毒署探员。
Wagner Moura在剧中扮演主要角色Pablo Escobar。他在白道是国会议员，在黑道则是以麦德林黑帮贩毒集团的领袖，一个臭名昭著的恐怖分子。他表面上是个很顾家的男人，而且经常做出一些劫富济贫的事情来提高自己的形象，因此被穷人尊为「新时代的侠盗罗宾汉」。
Boyd Holbrook扮演西弗吉尼亚禁毒署探员Steve Murphy
Pedro Pascal扮演墨西哥禁毒署探员Javier Pena，他们奉美国政府的秘密命令一起前往哥伦比亚俘获并杀死大毒枭Escobar。Steve Murphy和Javier Pena这两个角色是虚构的，但Pablo Escobar的故事却是真实的（时间大约在上世纪80年代末，90年代初）。
Manolo Cardona扮演全国总监狱长Eduardo Mendoza，他长着一张娃娃脸，没有什么经验，心肠很好，充满理想主义，像个长不大的孩子。—天涯小筑
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