《撕裂人/魔虫口入》讲述在宁静祥和的维尔西小镇，商人格兰特(迈克尔·洛克尔饰)和年轻貌美的妻子斯达拉(伊丽莎白·班克丝饰)享有一栋豪宅及巨额银行存款，在镇上的地位举足轻重，按理说，格兰特应该心满意足了，但家家都有本难念的经，年轻的斯达拉偏偏与他同床异梦。一天晚上，与妻子求欢不成的格兰特去当地一家酒吧买醉，巧遇老情人的妹妹布伦达(布伦达·詹姆斯饰)，相见甚欢的二人借着月色来到酒吧后面的树林中散步，突然，二人遇见了一块神秘的陨石，可怕的是，陨石裂开后，一只外星异种将满是脓泡的触手射入了格兰特的体内，倒霉的格兰特因此被异形寄生虫所感染。
格兰特的行为日渐异常，终日躲在家中的地下室里，对待斯达拉忽而温柔甜蜜，忽而狂暴异常。一段时间之后，当地的许多宠物和农场动物陆续失踪，格兰特家中不时传出怪声和尸臭味。更恐怖的是，镇上开始繁殖出大量粘腻发亮的巨型蛞蝓(通称鼻涕虫)，所有被攻击的居民都变成了嗜血僵尸。勇敢的斯达拉和警长比尔(内森·费林饰)合力拼命阻止感染人群的扩散，小镇上人人自危，所有没被感染的居民们不但要躲避巨型蛞蝓从口中入侵他们体内，同时要避开变成嗜血僵尸的邻居。居民们在同心协力阻止弥漫整个小镇的邪恶生物的同时，还在相互猜忌对方是否受到蛞蝓的侵害，一场爆笑而骇人的生存大战由此展开……
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