有的时候，所谓明智的决定，只是代表着大多数人的利益而已……2008年，出现了一种靠皮肤接触就能够传染的致命病毒，感染了数百万的人口，使苏格兰直接陷入了瘫痪之中。英国的政府机构想不出任何良策来控制病毒，只能宣布苏格兰为疫区，隔离了那里所有的平民，期望能借此控制住病毒的传播。每一条高速公路、高架桥和铁路，都有军队把守，严禁任何车辆进出的同时，还修建了高高的钢铁围墙以加固封锁，现在苏格兰彻底地变成了一块被人遗忘的“死亡之地”，成了病毒肆虐的天堂。 2033年，病毒再次爆发，这次竟然发生在了人口高度集中的伦敦，看来政府25年前做出的那次所谓“保护大多数人生命”的如意算盘，是彻底落空了。国家安全局的长官比尔·纳尔逊受到首相迈克尔·卡纳里斯的召见，他向比尔展示了卫星拍到的照片，显示“疫区”里仍然有人活着的迹象--有幸存者，就意味着那里有抵抗病毒的办法。 比尔迅速召集了一批他手下最优秀的专家，决定冒着风险进入那块已经被遗忘的孤独之地，找到对抗病毒的反作用药剂。这次行动的指挥官是作风颇为强悍的伊登·辛克莱，她带领着队员们踩着满大街的尸体，进入了那片被遗弃的疫区，却惊讶地发现，这块被隔离了25年的地方，早就变成了荒蛮之地，里面满是凶狠、充满野性的幸存者，而且在无政府的状态下，衍生出了类似于部落之间的派系争斗。伊登和她的队员不幸地走进了两个嗜血成性的派别之间的夹缝中，只能不断地战斗，才能在这里争取到生存的权力。
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