《万夫莫敌》取材于美国历史上著名橄榄球选手文斯·帕培尔的真实经历，影片讲述了他从几乎一无所有到克服重重困难、最终实现梦想的故事。
妻子过世后，30岁的文斯连工作也丢了，只能做代课教师，一事无成、霉运不断的他为了生活甚至要在酒吧做兼职招待。虽然酷爱橄榄球运动，但他甚至没在大学队里打过球。就在人生最潦倒的时候，他最钟爱的小镇橄榄球队教练做出一个史无前例的重要决定，面向社会公开选拔球员。所有人都觉得这只是浪费时间，职业球员怎么可能这样被发掘出来。文斯偏偏不信邪，决意要通过这个途径实现自己毕生最疯狂的梦想，他出人意料地被球队录取，并开始了职业球员的生涯。已是而立之年的他加入球队之初，受尽怀疑和白眼，但他凭借不懈的努力和自身条件，终于赢得了掌声和喝彩，摆脱了底层的地位，成为一位事业辉煌的职业球员。
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