在首集电影里偷月失败后，身为大犯罪家的格鲁，是带着三个漂亮可爱的养女，过起平淡而欢乐的家庭生活？还是又会与黄色小兵们一起策划更大的惊天计划？
环球公司首部3D动画片《卑鄙的我》（Despicable Me）以6000万美元的成绩勇夺北美票房冠军，环球公司就高兴的宣布，他们将为这部动画片制作续集和外传。
自从与玛戈、伊迪丝和阿格蕾丝三个可爱的小女孩实现宿命的邂逅，曾经的大坏蛋格鲁可真彻底转型了，他金盆洗手，转而化身为慈祥可亲的爸爸和做得一手烂口味布丁果冻的商人。当然凡事没有尽善尽美的，在此期间，憧憬大坏蛋传奇人生的老搭档纳法利欧博士离他而去，另谋高就。某天，格鲁被身怀绝技却鲁莽的特工露西·王尔德绑架，原来露西所在的集团研制出可以改变生物基因的药物，可他们位于北极的实验室被神秘窃贼偷走，因此才委托有过坏蛋经验的格鲁做卧底。经过一番考虑，格鲁接受了这项任务，带着超萌的小黄人们，和露西组成了爆笑连连的追凶搭档。
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