上演一个个中国刑警的惊险故事。更年轻的队伍，更激烈的打斗，更复杂的案情，同样让你欲罢不能。 我公安刑警杨震（丁志成饰）打入犯罪集团做卧底，突然面临被识破的危险，季洁（王茜饰）、郑一民（张潮饰）率重案六组刑警紧急前往解救……神秘的电子邮件，是黑客入侵？是恐吓勒萦？还是病毒？可怕的放射物质外泄，是恐怖事件？还是意外事故？……大案重案，一案接一案，案情扑朔迷离，危机四伏，紧急万分！面对一系列高科技犯罪案，重案六组全力追查，真相一步步浮出水面……经历生死的考验，常保乐（侣萧饰）与各办案人员的情谊更加深厚，季洁对杨震日渐生情，丁箭（王挺饰）开始暗恋田蕊（孙菲菲饰）…… 一年前，《重案六组Ⅰ》就以快节奏、艺术写实以及真实的侦破高智能犯罪案，使得全国上下掀起了一股“警匪剧潮”，因此在创作第二部的时候就很自然地保留了这种风格。为了增强《重案六组Ⅱ》故事的可看性，导演和编剧们不仅增加了大量的动作戏和枪战场面，还第一次启用了真家伙。
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