医生王再来与设计咨询师田丽丽是一对生活幸福的小夫妻。王家老房子突然被划入重点小学“学区房”，丈母娘原本就对他俩婚房首付是老田家出的这事不满，正好借让外孙鸣鸣可以上重点小学，把原来答应的房子过户到再来和丽丽的名下。 谁曾想老王已经决定卖掉房子，还准备与自己家的保姆裴阿姨再婚。王再来的弟弟王再龙与妻子肖燕分分合合，王再来在老爸、弟弟、老婆、丈母娘之间周旋，一度也游刃有余。但没想到大学女友ECHO、青睐自己老婆的合作方老板赵丰林的相继出现，令王再来捉襟见肘，也令原本恩爱的两个人越走越远。最终，王再来以百战不殆的精神，不厌其烦，左右逢源，用感情和信任战胜了猜忌，用亲情弥合了世俗利益造成的鸿沟。亲人更亲，夫妻深爱。
凯歌与肖燕举行婚礼
丽丽找借口向葛经理请了病假，暂时退出了项目，尽量避免和赵总再见面。葛经理带着刘美美到艾美谈合同，但赵总一直都借口事务繁忙避而不见。凯歌的作品终于得到了公众的认可，颁奖礼上，凯歌向肖燕深情告白，再次求婚，燕子答应了。凯歌决定和肖燕重新举办一场婚礼。王父想帮凯歌大办一场，找凯旋商量，凯旋和丽丽欣然同意…
凯旋约丽丽吃饭，王凯旋说怕田丽丽跟着他没法幸福，两人分手，与此同时，刘美美将偷来的策划案交给张哥。艾可约田丽丽见面，告诉丽丽真相，说自己要跟刘向前努力幸福，希望她跟凯旋也能幸福下去，田丽丽百感交集。裴阿姨来田丽丽公司跟她对万强的事情道歉，告诉她凯旋不是老王亲生儿子的真相。车店经理为了满足凯旋在结婚…
裴阿姨发现老王的秘密丽丽产生婚姻危机感
艾可和社区医院院长谈新项目合作，为了避嫌，她提出想换一位大夫合作，院长同意了。艾可觉得刘向前利用职权压制凯旋升职的事情因自己而起，所以她提出可以帮凯旋换家医院，凯旋答应考虑一下。老王和裴阿姨偷偷跑回自己家看看，见老王带着存折匆匆而去，不放心的裴阿姨悄悄尾随老王来到敬老院。趁老王为老太太缴费的时候，…
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