《流氓太医》一个关于皇朝医术故事集身份对换、爱情、友情、亲情冲突和矛盾戏剧性浓烈孙耀威卸下儒雅形像当上捣蛋小流氓一展搞笑天份；国内名旦罗海琼、李小冉靓丽造型演技使人刮目相看；任泉形像大变格表现超凡与及台湾笑匠李立群等大联手剧中彻底颠覆了皇家太医给人斯文、迂腐印象以强化喜剧元素将中国古老医道再现萤幕 永乐年间，惠帝撤藩燕王朱棣挥军入京，惠帝失踪，朱棣即位为成祖，二十年成祖励精图治，国泰民安。平一姑与其子平常初到京城以假医术骗人赚点小钱！ 平常赌坊遇一名似流浪汉王九三人结伴而行，天命为郑和医病平常佩服王九暗助下投其门下！并和天命得意门生农草堂成为朋友 天命之女素问患有性格分裂性，另一身份灵枢素问与平常经常接触二人产生感情；草堂与灵枢也互生情愫。可王九医治素问手术後只留下了灵枢，令平常失去挚爱。王九租捕头粟米房开起医馆天命前来寻不死药。原来，王九当年医神农金匮另一弟子王宵天命发现了平常医学天份将其赶出医馆，平常做了王九首徒一名叫竹利幸福日本人来向天命、王九问道王九取胜幸福拜王九为师幸福认识了自幼无父母由爷爷带大且双目失明小猪寄情众人努力医治下小猪重见光明与幸福也有了圆满结局 王九与前来讨租粟米妹妹不足日久生情，可始终难忘已去世天命之妻芍药逃情路上遇昏迷雷蕾带回医治雷蕾到来及其与王九言行令不足醋味十足後雷蕾感激众人照顾下依依不舍离去王九与不足感情有了发展平常大家动员下刻苦习医与草堂一齐参加太医考劾二人皆被录取身为太医平常并不习惯官僚生活 一姑发现草堂自己儿子但天命威胁下不敢相认原来当年有恩於一姑农金匮抱其子被追杀一姑感恩将二子对换平常实则医神农金匮之子！草堂得知後却不愿接受事实後一姑为救草堂而死幸福之父竹利义满率日本武士前《流氓太医》主人公(10张)来要协助蛰伏民间图谋复位惠帝推翻成祖！惠帝并收买了天命与草堂成祖及众臣受害身中剧毒危急关头被平常、幸福救之惠帝功败垂成自尽，灵枢亦记起了素问一切终和平常走到了一起……
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