《大秦帝国之天下》是由西安曲江大秦帝国影业投资有限公司出品，延艺执导，朱珠领衔主演的古装历史剧。战国晚期，秦国独大。一代雄主秦昭襄王与承位之秦孝文王相继离世，秦廷陡现嫡庶之争。巨贾吕不韦阳谋篡国，扶植流亡在外的公子异上位。长公子嬴奚恨别咸阳。
政乱平定，秦伐六国，渐有一统天下之势。惟与宿敌赵国之战，败绩频乃，且将星凋零，民苦国累，秦赵结仇愈深。王子嬴政与母亲赵姬返秦之后，在仲父吕不韦的训教下，母后的呵护下，显王者之尊。为了儿子的王位，赵姬与吕不韦联手，打压华阳夫人为首的楚系。而嬴政用王弟成蟜之血，洗清通向王位的道路；污秽内宫的嫪毐日益做大，且有篡国之念。嬴政利用吕不韦、宗室嬴奚，铁腕涤荡嫪毐之乱。动乱平息，嬴政再无情驱逐母后赵姬，贬相国吕不韦。至此，嬴政揽政于手，主国于秦 。
战国晚期，纷乱五百余年的华夏大地仍战火不息、生灵涂炭。彼时六国势弱、秦国独强，天下统一之势渐显。巨商吕不韦携时在赵国为质的嬴异人逃归秦国，幼小的始皇帝嬴政被弃留邯郸，屡遭生死劫难，也目睹战争带给百姓的痛苦与绝望，心中天下凝一之志由此而生。此后嬴政归秦，在咸阳政治漩涡中经历精神阵痛，蜕变成一个真正王者。为抓住一统天下的时机和力量，实现一统天下的理想抱负，精心谋划，暗中行动，终于平定嫪毐之乱，亲政，罢相，收复王权。此后又铲除宗室复辟势力，为东出灭国扫清障碍。在李斯、王翦、蒙恬等一般文臣武将的辅佐下扫灭六国，建立起中华历史上第一个大一统的中央集权国家。
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