《碧血书香梦》是一部年代女性励志大戏。该剧由张檬、韩栋、巍子、吴倩、茅子俊等领衔主演。
该剧讲述了辛亥革命胜利之后的民国初年，江南才女沈碧云为了实现进入中国最大的私人藏书楼博览群书、为所有学子争取读书的权利的理想，也为了探查杀父仇人，不惜以终生幸福为赌注，嫁入江南最大私家藏书馆之主宣家，却陷入了重重危机所遭遇的故事。
辛亥革命胜利之后的民国初年，江南才女沈碧云为了实现进入中国最大的私人藏书楼博览群书、为所有学子争取读书的权利的理想，也为了探查杀父仇人，不惜以终生幸福为赌注，嫁入藏书楼之主的宣家，却由此陷入宣家内部的勾心斗角、争权夺利漩涡，遭遇重重危机，尝尽人情冷暖，几度出生入死。宣家也经历了一次次浩劫，直至家破人亡，碧云仍然矢志不渝，在宣家三少爷宣孝季和进步青年吴时的帮助下，凭着坚强的信念和过人的智慧拯救了宣家，成为宣家新当家人，并查清真凶，报得父仇。最终，沈碧云冲破封建祖制开放书楼，包括碧云在内的莘莘学子得以登楼读书。
沈父坟前，丁丹萍向宣孝季承认毒害了沈父，包括金豆患病身亡也是她从中做梗，嫁入宣府多年，她做了许多伤天害理之事，已经不想再苟且偷生下去，能死在宣孝季手中，倒是不错的归宿。宣孝季心慈手软不忍心杀害丁丹萍，盛怒之下命其不得再返回宣府，从此以后，宣府不再有丁丹萍这个人。沈碧云在丁丹萍的邀请下乘船游江，两人在…
沈碧云找丁丹萍对质，丁丹萍承认自己换了堕胎药给陈阿英服食，致其流产痛失爱子，而这一切被已故的宣泽恩知悉，他没有拆穿丁丹萍的底细，而是顺水推舟将责任归结到沈碧云身上，将其赶出宣府。一切都是丁丹萍片面之词，宣泽恩已经身亡无法证实事情真假。丁丹萍的为人沈碧云已经看清，她悲愤交加意识到自己被丁丹萍利用，此时…
宣泽恩为保后辈们的性命，宁愿只身一人与书楼共存亡，后辈们眼睁睁看着他迈动步子进入书楼，关闭大门举火引燃整幢书楼。临死之前，宣泽恩往楼外扔出一本燃烧的书册，至死不肯向柳川示软，书楼转眼功夫被大火包围，宣泽恩在大火中与书楼化为灰烬，死得其所。柳川不甘心还想寻找宣家藏书，沈碧云坚称藏书已经全部烧毁，宣泽恩…
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