多次恋爱失败的经验使得心理医生Selina(刘嘉玲)患上了婚姻恐惧症。而另外她的几位好友也都是志同道合的单身女性——包括尖酸刻薄的女作家关德娴(朱茵)，爱好刺激活动的倪险(蒙嘉慧)，好抱打不平的Mark姐(张文慈)等等。不过这一次几位美女却同时碰上了桃花运：Selina爱上了江湖大哥任初九(梁家辉饰...)，而这位大哥却是一位心肠极好的人；蒙在鼓里的关德娴却同时爱上了一对父子——政治评论家石大班(许绍雄)与英俊大学生Stone(陈冠希)，却无法做出选择，只好脚踏两只船；Stone的好友，内地专才“大胆”(陆毅饰) 对倪险一见钟情，发誓两星期内要追到手；性格粗鄙火爆的丑女尤蒂(张柏芝饰)，与保镖许劲(许志安饰)喜结良缘。几位美女竞相撞上桃花运，经过一番历险之后，各得其所。
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