影片讲述意大利男子和中国女子相遇在纽约，这对文化背景迥异的男女渐渐擦出火花，坠入爱河的有趣爱情故事。
爱情喜剧《曼哈顿爱情故事》由曾成功执导《全民情敌》、《安娜与国王》等好莱坞佳作的著名导演安迪·坦纳特再次掌镜，奥斯卡影帝阿德里安·布劳迪与中国女演员倪妮联袂担纲男女主演，共同打造一段唯美的跨越国界的爱情。
女主（倪妮饰），一个来自中国的曼妙少女，
男主（阿德里安•布劳迪饰），一个来自意大利的浪漫男孩，
本是来自两个不同国家的陌路人，在缘分的牵引下，他们相遇了、邂逅了、相知了、相恋了。
他们的爱情，超越了地域、超越了肤色、超越了国界……
若是相爱，万水千山都难成阻碍；若为虚情，近在咫尺的爱恋亦是羁绊。
10年前，一部《全民情敌》让纽约成为与浪漫之都“巴黎”齐名的约会圣地；
10年后，《全名情敌》导演安迪•坦纳特再次将目标选定在繁华都市纽约，演绎曼哈顿的爱情故事。
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